Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI)

Calculator

When to use

Arrhythmia

None

Atrial fibrillation, atrial flutter, sick sinus syndrome, or ventricular arrhythmias

Cardiac disease

None

Coronary artery disease, congestive heart failure, myocardial infarction, or ejection fraction ≤ 50%

Valvular disease

None or mitral valve prolapse

Other valvular disease

Inflammatory bowel disease

None

Crohn's disease or ulcerative colitis

Diabetes

None or controlled by diet alone

Requiring treatment with oral hypoglycemics or insulin

Cerebrovascular disease

None

Cerebrovascular accident or transient ischemic attack

Psychiatric conditions

None

Depression or anxiety requiring psychiatric consultation or treatment

Hepatic dysfunction

None

Chronic hepatitis, bilirubin up to 1.5× upper limit of normal or aspartate aminotransferase/alanine transaminase up to 2.5× upper limit of normal

Liver cirrhosis, bilirubin >1.5× upper limit of normal or aspartate aminotransferase/alanine transaminase >2.5× upper limit of normal

Obesity

Body mass index ≤ 35 kg/m²

Body mass index > 35 kg/m²

Infection

None

Requiring continuation of antimicrobial therapy after day 0

Rheumatologic diseases

None

Systemic lupus erythematosus, rheumatoid arthritis, polymyositis, mixed connective tissue disease, or polymyalgia rheumatica

Peptic ulcer disease

None or not requiring treatment

Requiring treatment

Renal dysfunction

None or serum creatinine ≤ 2 mg/dL

Serum creatinine > 2 mg/dL, on dialysis, or prior renal transplantation

Pulmonary dysfunction

None or diffusion capacity of the lung for carbon monoxide and/or forced expiratory volume in 1 second > 80%

Diffusion capacity of the lung for carbon monoxide and/or forced expiratory volume in 1 second 66-80% or dyspnea on slight activity

Diffusion capacity of the lung for carbon monoxide and/or forced expiratory volume in 1 second ≤ 65% or dyspnea at rest or requiring oxygen

Prior solid tumor

None or nonmelanoma skin cancer

Treated at any time point in the patient's past history

Calculation

Please enter all the required inputs.

The Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) is a clinical calculator used in the field of hematology, specifically for patients who are candidates for hematopoietic cell transplantation (HCT). This scoring system is designed to predict the risk of non-relapse mortality following HCT by assessing the presence and severity of various comorbidities. The HCT-CI includes a range of conditions such as heart disease, lung disease, liver disease, renal disease, and others. The higher the score, the greater the risk of non-relapse mortality post-transplant. This tool is particularly useful in helping clinicians make informed decisions about the appropriateness of HCT for a given patient and in discussing potential risks and benefits with patients. It is not applicable to patients who are not candidates for HCT or those with conditions not included in the index.

Reference

Mohamed L Sorror, Michael B Maris, Rainer Storb et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005 Oct 15;106(8):2912-9.

Open reference URL

Create free account