The calculator in question is the International Tuberous Sclerosis Complex Consensus Group's (ITS) diagnostic criteria for tuberous sclerosis complex (TSC). This calculator is used in the diagnosis of TSC, a genetic disorder that causes non-cancerous (benign) tumors to grow in many parts of the body. The ITS diagnostic criteria are applicable to individuals of all ages, from infants to adults, who are suspected of having TSC.
The clinical utility of this calculator lies in its ability to guide clinicians in diagnosing TSC based on a combination of major and minor features that are characteristic of the disease. These features include various skin abnormalities, neurological symptoms, and the presence of tumors in organs such as the brain, kidneys, heart, lungs, and eyes.
There are no specific exclusion criteria for the use of the ITS diagnostic criteria for TSC. However, it should be noted that the presence of one or more of these features does not definitively confirm a diagnosis of TSC, and genetic testing may be necessary for a definitive diagnosis. The ITS diagnostic criteria should therefore be used in conjunction with other diagnostic tools and clinical judgement.
Reference
Hope Northrup, Darcy A Krueger, International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 Iinternational Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 2013 Oct;49(4):243-54.
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