Maddrey's Discriminant Function for Alcoholic Hepatitis is a prognostic index designed to predict mortality risk in patients with alcoholic hepatitis. The clinical purpose of this tool is to aid in the identification of patients who may benefit from corticosteroid therapy, with a particular focus on those with severe alcoholic hepatitis. The key components used in Maddrey's Discriminant Function include prothrombin time (PT), control PT, and total bilirubin levels. These parameters are essential in determining the severity of the disease and the subsequent risk of mortality.
Reference
W C Maddrey, J K Boitnott, M S Bedine et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978 Aug;75(2):193-9.
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