PLASMIC score for ADAMTS13 deficiency

Calculator

When to use

Platelet count < 30×10**9/L

Yes

Hemolysis (indirect bilirubin > 2.0 mg/dL, uncorrected reticulocyte > 2.5% or undetectable haptoglobin)

Yes

Active cancer in the previous year

Yes

History of solid-organ or stem-cell transplant

Yes

MCV < 9.0×10-14 L [< 90 fL]

Yes

INR < 1.5

Yes

Creatinine < 2.0 mg/dL [< 176.8 mcmol/L]

Yes

Calculation

Please enter all the required inputs.

The PLASMIC score is a clinical calculator used to assess the likelihood of severe ADAMTS13 deficiency in patients with suspected thrombotic thrombocytopenic purpura (TTP). ADAMTS13 is a protein that helps prevent blood clots from forming, and a deficiency can lead to TTP, a rare blood disorder that can cause blood clots to form in small blood vessels throughout the body. The PLASMIC score stands for "Platelet count, hemolysis, no active cancer, no history of solid organ or stem cell transplant, Mean Corpuscular Volume (MCV), International Normalized Ratio (INR), and Creatinine". Each of these factors is assigned a point value, and the total score is used to predict the likelihood of severe ADAMTS13 deficiency. This calculator is specifically applicable to adult patients presenting with microangiopathic hemolytic anemia and thrombocytopenia, where TTP is a consideration in the differential diagnosis. It helps clinicians decide whether urgent plasma exchange therapy is needed, and aids in the early identification and treatment of TTP. The PLASMIC score should not be used in patients with active cancer, a history of solid organ or stem cell transplant, or in children, as it

Reference

A Li, P R Khalighi, Q Wu et al. External validation of the PLASMIC score: a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis and treatment. J Thromb Haemost. 2018 Jan;16(1):164-169.

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