The RIFLE criteria for diagnosing acute kidney injury involve assessing the severity based on changes in serum creatinine, glomerular filtration rate (GFR), and urine output. Based on user input, the criteria determine a classification level: Risk, Injury, Failure, Loss, or End-stage Renal Disease (ESRD).

Here's how the computation works:

- **Risk, RIFLE-R**: Identified when the serum creatinine level is 1.5 to 2 times above baseline, or the GFR shows more than a 25% decrease below baseline. Urine output is less than 0.5 mL/kg/hour for 6 hours.
  
- **Injury, RIFLE-I**: Occurs if the serum creatinine level is more than 2 to 3 times above baseline, or there is more than a 50% decrease in GFR below baseline. This stage includes urine output less than 0.5 mL/kg/hour for 12 hours.
  
- **Failure, RIFLE-F**: Determined when serum creatinine exceeds 3 times above baseline or reaches 4 mg/dL (350 mcmol/L) or an acute rise of at least 0.5 mg/dL (44 mcmol/L). It also indicates a GFR decrease of over 75% below baseline. Urine output is critically low, at less than 0.3 mL/kg/hour for 24 hours, or anuria (complete absence of urine) for 12 hours.
  
- **Loss, RIFLE-L**: Describes persistent acute kidney injury lasting over 4 weeks.
  
- **ESRD, RIFLE-E**: Represents end-stage renal disease extending for more than 3 months.

The user's input concerning these criteria leads to a categorical diagnosis aligning with the RIFLE classification system, providing a structured perspective on the severity and progression of acute kidney injury.

The RIFLE criteria is a clinical calculator used to classify the severity of acute kidney injury (AKI). The acronym RIFLE stands for Risk, Injury, Failure, Loss, and End-stage kidney disease. This scoring system applies to patients who are at risk of developing AKI, particularly those in critical care settings such as the intensive care unit.

The RIFLE criteria is used to identify and stratify the severity of AKI based on changes in serum creatinine levels, glomerular filtration rate (GFR), and urine output. It helps clinicians to determine the appropriate treatment strategy and predict patient outcomes.

There are no specific exclusion criteria for the use of the RIFLE criteria. However, it may not be applicable or accurate in patients with chronic kidney disease or other conditions that affect baseline creatinine levels or urine output. It's also important to note that the RIFLE criteria does not identify the cause of AKI, so further diagnostic evaluation may be necessary.

RIFLE diagnostic criteria for acute kidney injury