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Achalasia
What's new
Updated 2024 AGA guidelines for peroral endoscopic myotomy in achalasia .
Background
Overview
Definition
Achalasia is an esophageal motility disorder defined by loss of esophageal peristalsis and incomplete relaxation of lower esophageal sphincter.
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Pathophysiology
Proposed causes of achalasia include GEJ obstruction, neuronal degeneration, viral infection, genetic inheritance, and autoimmune disease.
2
Disease course
Inflammatory neurodegenerative insult with possible viral involvement within the esophagus results in achalasia, which causes the clinical manifestation of progressive dysphagia, regurgitation, chest pain, heartburn, nocturnal cough, aspiration, and weight loss. The progression of the disease may result in aspiration-pneumonia, Barrett's esophagus, and esophageal cancer.
3
Prognosis and risk of recurrence
Achalasia is not associated with an increase in mortality.
4
Guidelines
Key sources
The following summarized guidelines for the evaluation and management of achalasia are prepared by our editorial team based on guidelines from the American Society for Gastrointestinal Endoscopy (ASGE 2025,2020,2014), the European Society for Neurogastroenterology and Motility (ESNM/UEG 2025), the American Gastroenterological Association (AGA 2024), the European Society of Gastrointestinal Endoscopy (ESGE 2020), the International Society for Diseases of the Esophagus ...
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