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Autism spectrum disorder

Background

Overview

Definition
ASD comprises a heterogeneous group of neurodevelopmental disorders characterized by early-onset deficits in social communication as well as restricted and repetitive interests and behaviors.
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Pathophysiology
ASD is associated with alterations in brain connectivity resulting from a complex interaction of genetic, epigenetic and environmental factors.
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Epidemiology
The prevalence of ASD in the US is estimated at 1,250-2,410 persons per 100,000 population.
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Disease course
Clinical manifestations include developmental delay, deficits in social interaction, communication, and repetitive/restricted behaviors. Approximately 75% of patients with ASD have comorbid psychiatric conditions including anxiety, depression, attention-deficit hyperactivity disorder, bipolar disorder, and Tourette syndrome.
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Prognosis and risk of recurrence
Individuals with ASD have an estimated excess mortality rate ratio of 5.6. Associated medical disorders (including epilepsy with cognitive impairment) and accidents account for most of the deaths.
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Guidelines

Key sources

The following summarized guidelines for the evaluation and management of autism spectrum disorder are prepared by our editorial team based on guidelines from the World Health Organization (WHO 2023), the British Association for Psychopharmacology (BAP 2019,2018), the U.S. Preventive Services Task Force (USPSTF 2016), and the American Academy of Child and Adolescent Psychiatry (AACAP 2014).
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