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Generalized anxiety disorder
Background
Overview
Definition
GAD is a chronic disorder characterized by excessive anxiety and worry about a number of events or activities (such as work, home, and social) symptoms, and tension, which an individual finds difficult to control.
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Pathophysiology
GAD is mostly caused by genetic (altered DNA methylation and single nucleotide polymorphism) and environmental factors (stress, trauma, etc.).
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Epidemiology
The lifetime prevalence of DSM-5 GAD in the US is estimated at 7,800 cases per 100,000 individuals.
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Disease course
Clinical manifestations include restless feeling, fatigue, difficulty concentrating, irritability, muscle tension, sleep disturbance, arguments with relatives or friends, difficulty/inability to complete tasks, restriction of usual activities, with associated autonomic, cardiovascular, respiratory, gastrointestinal, and urinary symptoms decreasing the overall health of the individual. GAD is associated with various comorbidities including depression, dysthymia, bipolar I and II, panic disorder with/without agoraphobia, social phobia, specific phobia, substance use disorder, and personality disorders (avoidant, dependent, obsessive-compulsive, paranoid, schizoid, and antisocial).
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Prognosis and risk of recurrence
Anxiety disorders are associated with an increased risk of death with a natural mortality rate ratio of 1.39 (95% CI 1.28-1.51) and an unnatural mortality rate ratio of 2.46 (95% CI 2.20-2.73).
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Guidelines
Key sources
The following summarized guidelines for the evaluation and management of generalized anxiety disorder are prepared by our editorial team based on guidelines from the American College of Obstetricians and Gynecologists (ACOG 2023), the European Society of Medical Oncology (ESMO 2023), the Society for Integrative Oncology (SIO/ASCO 2023), the U.S. Preventive Services Task Force (USPSTF 2023,2022), the World Health Organization (WHO ...
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