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Histoplasmosis

What's new

The Infectious Diseases Society of America (IDSA) has released a focused update on histoplasmosis. For asymptomatic non-calcified pulmonary nodules (histoplasmomas), routine antifungal treatment for preventing reactivation is not recommended. In immunocompetent patients, antifungal treatment is suggested for moderate acute pulmonary histoplasmosis but not for mild disease. In immunocompromised patients at risk of progression to disseminated disease, antifungal treatment with itraconazole is suggested for mild or moderate acute pulmonary histoplasmosis. .

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of histoplasmosis are prepared by our editorial team based on guidelines from the Infectious Diseases Society of America (IDSA 2025,2007), the U.S. Department of Health and Human Services (DHHS 2025), the European Confederation of Medical Mycology (ECMM/ISHAM 2021), the Pan American Health Organization (PAHO/WHO 2020), and the American Thoracic Society (ATS ...
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Classification and risk stratification

Severity assessment
As per PAHO/WHO 2020 guidelines:
Define severe or moderately severe histoplasmosis as the presence of at least one sign or symptom involving vital organs:
respiratory or circulatory failure
neurological signs
renal failure
coagulation anomalies
general alteration of the WHO performance status > 2, in which the person is confined to a bed or chair for more than half the waking hours and only capable of limited self-care
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Define mild-to-moderate histoplasmosis as signs and symptoms not including the above features defining severe or moderately severe histoplasmosis.
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Diagnostic investigations

Antigen testing: as per PAHO/WHO 2020 guidelines, obtain circulating Histoplasma antigens for the diagnosis of disseminated histoplasmosis in patients with HIV infection.
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Diagnostic procedures

Histopathological analysis: as per ECMM/ISHAM 2021 guidelines, obtain tissue for the histopathological diagnosis of histoplasmosis using fungal stains (Grocott methenamine silver staining) and fungal culture whenever possible.
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Medical management

Management of asymptomatic pulmonary nodules: as per IDSA 2025 guidelines, avoid initiating routine treatment for histoplasmosis to prevent reactivation in adult and pediatric patients with asymptomatic non-calcified pulmonary nodules related to histoplasmosis (histoplasmomas), with no evidence of other active sites, or in asymptomatic patients with known untreated prior infection.
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More topics in this section

  • Management of acute pulmonary histoplasmosis (mild-to-moderate)

  • Management of acute pulmonary histoplasmosis (severe)

  • Management of progressive disseminated histoplasmosis

  • Management of chronic cavitary pulmonary histoplasmosis

  • Management of broncholithiasis

  • Management of pericarditis

  • Management of mediastinal lymphadenitis

  • Management of mediastinal granuloma

  • Management of fibrosing mediastinitis

  • Management of CNS histoplasmosis

  • Management of rheumatologic syndromes

Specific circumstances

Pediatric patients: as per IDSA 2007 guidelines, apply the same treatment indications and regimens in pediatric patients similar to adult patients, except that amphotericin B deoxycholate (1.0 mg/kg/day) is usually well tolerated and lipid preparations are not preferred.
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More topics in this section

  • Pregnant patients

  • Patients with HIV (primary prophylaxis)

  • Patients with HIV (management of mild-to-moderate pulmonary disease)

  • Patients with HIV (management of severe pulmonary disease)

  • Patients with HIV (management of chronic pulmonary disease)

  • Patients with HIV (management of meningeal disease)

  • Patients with HIV (therapeutic drug monitoring)

  • Patients with HIV (management of tuberculosis co-infection)

  • Patients with HIV (secondary prophylaxis)

Preventative measures

Antifungal prophylaxis: as per DHHS 2025 guidelines, initiate primary prophylaxis in patients with a cluster of differentiation count < 150 cells/mm³ and at high risk because of occupational exposure or residence in a community with a hyperendemic rate of histoplasmosis (> 10 cases/100 patient-years).
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