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Peripartum depression

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Updated 2024 SOGC guidelines for screening and management of perinatal mood and anxiety disorders .

Background

Overview

Definition
Peripartum depression is a mood disorder occurring during pregnancy or within the first year postpartum.
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Pathophysiology
The development of peripartum depression is believed to be influenced by a combination of hormonal changes, particularly in estrogen and progesterone, imbalances in neurotransmitters like serotonin, and psychosocial elements such as stress, lack of social support, and previous mental health issues.
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Epidemiology
The prevalence of peripartum depression in the US is estimated at 13-19% in females.
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Risk factors
Risk factors for postpartum depression include a history of depression, anxiety, or other mood disorders, high stress levels, inadequate support from a partner, adverse life events such as marital discord or financial instability, and lifestyle factors including sleep disruption, suboptimal self-care, and challenges with breastfeeding.
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Disease course
Clinically, peripartum depression presents with persistent feelings of sadness, anxiety, and irritability. Patients may experience a loss of interest or pleasure in activities they once enjoyed, changes in appetite or sleep patterns, and difficulty concentrating. In severe cases, there may be thoughts of self-harm or harming the infant.
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Prognosis and risk of recurrence
The prognosis of peripartum depression can be serious if left untreated. It can negatively impact maternal-infant bonding and child development and can also have detrimental effects on the overall health of the mother.
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Guidelines

Key sources

The following summarized guidelines for the evaluation and management of peripartum depression are prepared by our editorial team based on guidelines from the Society of Obstetricians and Gynaecologists of Canada (SOGC 2024), the American Academy of Family Physicians (AAFP 2023), the American College of Obstetricians and Gynecologists (ACOG 2023), the Canadian Task Force on Preventive Health Care (CTFPHC 2022), the ...
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