Screening and diagnosis

Classification and risk stratification

Perioperative care

Quality improvement

Patient education

Nonpharmacologic interventions

Therapeutic procedures

Respiratory support

Follow-up and surveillance

Specific circumstances

Preventative measures

Medical management

Surgical interventions

Inpatient care

Diagnostic procedures

Diagnostic investigations

Insufficient evidence to make a recommendation.

Strongly favor this test or intervention.

The TNM classification for iris melanoma calculator evaluates the stage of iris melanoma based on three inputs: tumor classification, lymph node classification, and metastasis classification. Each input is categorized into specific subtypes, allowing for a comprehensive assessment of the disease stage.

In the computation, each subtype is assigned a code letter:

1. Tumor Classification:
   - Tx: A
   - T0: B
   - T1a: C
   - T1b: D
   - T1c: E
   - T2a: F
   - T2b: G
   - T2c: H
   - T3: I
   - T4a: J
   - T4b: K

2. Lymph Node Classification:
   - Nx: L
   - N0: M
   - N1a: N
   - N1b: O

3. Metastasis Classification:
   - M0: P
   - M1: Q
   - M1b: R
   - M1c: S

The calculation then applies a set of logical conditions to determine the stage of iris melanoma:

- Stage I is determined if the tumor is limited to the iris in size (T1a) without lymph node (N0) or distant metastasis (M0).
- Stage IIA is assigned if the tumor is limited to the iris (T1b, T1c) or extends to the ciliary body without secondary glaucoma (T2a), while having no lymph node or distant metastasis.
- Stage IIB applies if the tumor extends into the ciliary body and choroid without secondary glaucoma (T2b), and there is no lymph node or distant metastasis.
- Stage IIIA encompasses tumors extending into the ciliary body, choroid with secondary glaucoma (T2c), or with scleral extension (T3, T4a), without lymph node or distant metastasis.
- Stage IIIB is designated for tumors with extrascleral extension greater than 5 mm (T4b) and no lymph node or distant metastasis.
- Stage IV is determined if there is metastasis in one or more regional lymph nodes (N1a) or the presence of discrete tumor deposits not contiguous with the eye (N1b), alongside no distant metastasis or any distant metastasis size (M0, M1, M1b, M1c).

If all conditions are met for a clear stage, the corresponding stage is identified. If data is missing or conditions do not fit the predefined stages, it returns a message indicating that the stage cannot be fully assessed or prompts for missing selections.

The output is a single result string specifying the computed stage of iris melanoma based on the provided classification inputs.

The calculator in question is the TNM Classification for Iris Melanoma. TNM stands for Tumor, Node, Metastasis, a system used for staging different types of cancer. This particular classification is specifically designed for iris melanoma, a rare form of eye cancer that originates in the iris, the colored part of the eye.

The TNM Classification for Iris Melanoma is used to determine the extent of the cancer in the patient's eye and whether it has spread to other parts of the body. It is a crucial tool for clinicians to decide the most appropriate treatment plan and to predict the patient's prognosis.

The TNM system for iris melanoma includes three components: T (Tumor) describes the size and extent of the primary tumor, N (Node) indicates whether the cancer has spread to nearby lymph nodes, and M (Metastasis) reveals if the cancer has metastasized to other parts of the body.

This classification system is specifically applicable to patients diagnosed with iris melanoma. It is not suitable for other types of eye cancer or melanoma located in other parts of the body. It also may not be applicable in cases where the patient has had previous cancer treatments that could affect the staging.

TNM classification for iris melanoma

The TNM classification calculator for ciliary body and choroid melanoma assigns stages to the condition based on user inputs related to tumor, lymph node, and metastasis classifications following specific criteria. Here's how the calculator systematically determines the stage:

1. The calculator takes three inputs from the user:
   - Tumor Classification (T)
   - Lymph Node Classification (N)
   - Metastasis Classification (M)

2. Each classification level is represented by a specific category:
   - Tumor Classification options range from Tx (Tumor cannot be assessed) to various detailed T categories (T0 to T4e).
   - Lymph Node options include Nx (Nodes cannot be assessed) to N1b (Discrete tumor deposits not contiguous to the eye).
   - Metastasis options range from M0 (No metastasis) to M1c (Largest metastasis >= 8.1 cm).

3. Determine the stage using the combination of these chosen classifications:
   - If tumor classification is T1a and lymph node classification is N0 with no distant metastasis (M0), the stage is identified as Stage I.
   - The stage progresses to Stage IIA, IIB, IIIA, IIIB, IIIC, and ultimately Stage IV based on specific combinations of tumor, lymph node, and metastasis options. For instance, T1b to T2d with N0 and M0 correspond to Stage IIA, while T3b with N0 and M0 results in Stage IIIB.
   - If regional lymph nodes show metastasis (N1a) or there are discrete tumor deposits (N1b) and metastasis is not explicitly distant (M0), or if any distant metastasis (M1, M1b, M1c) is confirmed, the condition is classified as Stage IV.

4. If the conditions do not map to any specific stage, the output will indicate that the stage cannot be fully assessed. This covers cases where classifications like Tx or Nx are selected, where assessment is inherently problematic without further information.

The calculator in question is the TNM Classification for Ciliary Body and Choroid Melanoma. TNM stands for Tumor, Node, Metastasis, a system used for staging different types of cancer. This specific TNM classification is applicable to patients diagnosed with melanoma of the ciliary body and choroid, which are parts of the eye.

The clinical utility of this calculator is to stage the severity of the cancer, which is crucial for determining the most appropriate treatment plan and for predicting prognosis. The TNM classification takes into account the size and extent of the primary tumor (T), whether the cancer has spread to nearby lymph nodes (N), and the presence of distant metastasis (M).

There are no specific exclusion criteria for the use of the TNM Classification for Ciliary Body and Choroid Melanoma. However, it is not applicable to other types of eye cancer or to melanoma located in other parts of the body. It is also less useful in cases where complete information about the tumor, nodes, and metastasis is not available.

Uveal melanoma

Guidelines

Key sources