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Alpha-1 proteinase inhibitor

Class
Serine protease inhibitors
Subclass
Neutrophil elastase inhibitors
Generic name
Alpha-1 proteinase inhibitor, A1-PI, alpha-1 antitrypsin
Brand names
Prolastin-C®, Zemaira®
Common formulations
Solution for injection, Kit for injection
Dosage and administration
Adults patients
Treatment of α-1 proteinase inhibitor deficency
•
60 mg/kg IV weekly
Indications for use
Labeled indications
Adults
•
Treatment of α-1 proteinase inhibitor deficency
Safety risks
Contraindications
A history of severe, hypersensitivity reactions to α-1-proteinase inhibitor products
•
Patients should be carefully screened for any known allergies or hypersensitivity to Alpha-1-proteinase inhibitor before administration.
IgA deficiency
•
Patients should be carefully screened for IgA deficiency before starting Alpha-1-proteinase inhibitor treatment.
Warnings and precautions
Viral infections, Creutzfeldt-Jakob disease
•
Use caution with risk factors for the transmission of infectious agents. Patients should practice good hygiene, to reduce the risk of viral transmission. Depending on the specific viral infection, antiviral medications or supportive care may be administered as per medical guidance.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
•
Use only if clearly needed.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Acute exacerbations of chronic obstructive pulmonary disease, ↑ liver enzymes, cough, headache, musculoskeletal pain, sinusitis, upper respiratory tract infections
Common 1-10%
•
Bronchitis, injection site hematoma, peripheral vasodilation, pharyngitis, asthenia, chest discomfort, dizziness, fever, generalized pruritus, injection site pain, nasal discharge, throat pain, rhinitis
Uncommon < 1%
•
Somnolence
Unknown frequency
•
Allergic reactions, ↑ WBC count, diarrhea, injection site reactions, nausea, skin flushing, vomiting, urticaria
Interactions
Drug(s)
Check Interactions
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