Diclofenac sodium DR
Class
Nonsteroidal anti-inflammatory drugs
Subclass
Acetates
Substance name
Diclofenac sodium DR
Common formulations
Tablet
See also
Diclofenac sodium (Zorvolex®, Voltaren®)
Diclofenac sodium ER
Diclofenac potassium (Cambia®, Zipsor®)
Diclofenac epolamine (Licart®, Flector®)
Dosage and administration
Adults patients
Symptomatic relief
Osteoarthritis
Treatment
Treatment of gout • Acute flare • Off-label
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Boxed warnings
Cardiovascular thrombotic events
Gastrointestinal bleeding, peptic ulcer disease, gastric perforation
Contraindications
Hypersensitivity to diclofenac or any of its components
In patients undergoing CABG surgery
Salicylate hypersensitivity or NSAID hypersensitivity
Warnings and precautions
Aseptic meningitis
Exacerbation of edema, HF
Exacerbation of hypertension
Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome, fulminant hepatic failure
Increased liver enzymes
Renal papillary necrosis, AKI
Specific populations
Renal impairment
eGFR > 60 mL/min/1.73 m²
eGFR 30-60 mL/min/1.73 m²
eGFR < 30 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
> 30 weeks of gestation
20-30 weeks of gestation
< 20 weeks of gestation
Breastfeeding
Use with caution during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
May potentially cause adverse effects in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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