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Nicardipine SR

Class
Antihypertensives
Subclass
Dihydropyridine calcium channel blockers
Generic name
niCARdipine hydrochloride SR
Brand names
Cardene SR®
Common formulations
Capsule
See also
Nicardipine (Cardene®)
Dosage and administration
Adults patients
Treatment of hypertension
•
Start at: 30 mg PO BID
•
Maintenance: 30-60 mg PO BID
Indications for use
Labeled indications
Adults
•
Treatment of hypertension
Safety risks
Contraindications
Hypersensitivity to nicardipine or its components
Advanced aortic stenosis
Warnings and precautions
Exacerbation of angina pectoris
•
Maintain a high level of suspicion, as nicardipine has been associated with increased frequency, duration, or severity of angina on starting therapy.
Exacerbation of HF
•
Use caution in patients with congestive HF, particularly with concomitant use of β-blockers.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Titrate slowly.
Renal replacement therapy
Any modality
•
Titrate slowly.
Hepatic impairment
Any severity
•
Use with caution.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: C
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Do not use during breastfeeding.
Low levels in breastfed infants (5-25%).
Adverse reactions
Common 1-10%
•
Peripheral edema, asthenia, dizziness, headache, nausea, palpitations, skin flushing
Uncommon < 1%
•
Myocardial infarction, orthostatic hypotension, diarrhea, tachycardia, skin rash, urinary frequency, sweating, vomiting, blurred vision, angina pectoris, facial edema
Rare < 0.1%
•
Infections, sinusitis, VT, ↑ liver enzymes, sore throat, arthralgia, hot flashes, vertigo, hyperkinesia, erectile dysfunction, depression, anxiety, confusion, nervousness, rhinitis, tinnitus, blurred vision, visual disturbances
Interactions
Drug(s)
Check Interactions
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