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Thioguanine

Class
Antimetabolites
Subclass
Purine analogs
Substance name
Thioguanine
Brand names
Tabloid®
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment of acute leukemia • Acute nonlymphocytic leukemia
•
2 mg/kg PO daily
Indications for use
Labeled indications
Adults
•
Treatment of acute leukemia (acute nonlymphocytic leukemia)
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Avoid use. Evidence of fetal harm in humans. This drug can harm a developing fetus.
•
Adequate methods of contraception should be encouraged.
•
If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
•
Women of childbearing potential should be advised to avoid becoming pregnant.
•
There have been cases where men who have received combinations of cytotoxic agents including this drug have fathered children with congenital abnormalities.
Breastfeeding
Do not use during breastfeeding.
Unknown amount excreted in breastmilk.
Undetectable levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
Adverse reactions
Unknown frequency
•
Bacillary peliosis hepatis, drug-induced liver injury, gastrointestinal perforation, hepatic veno-occlusive disease, ↑ liver enzymes, ↑ serum uric acid, pancytopenia, loss of appetite, nausea, vomiting, stomatitis
Interactions
Drug(s)
Check Interactions
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