ABC-Sepsis
Trial question
What is the role of albumin for early resuscitation in patients with sepsis?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
50.0% female
50.0% male
N = 300
300 patients (149 female, 151 male).
Inclusion criteria: adult patients with sepsis.
Key exclusion criteria: requirement for immediate surgery; chronic RRT; known allergy/adverse reaction to human albumin solution; known adverse reaction to blood products; recent severe traumatic brain injury.
Interventions
N=150 albumin (intravenous fluid resuscitation with 5% human albumin solution in the the first 6 hours).
N=150 balanced crystalloids (intravenous fluid resuscitation with balanced crystalloid in the the first 6 hours).
Primary outcome
Death at day 30
21.1%
14.8%
21.1 %
15.8 %
10.6 %
5.3 %
0.0 %
Albumin
Balanced
crystalloids
No significant
difference ↔
No significant difference in death at day 30 (21.1% vs. 14.8%; OR 1.5, 95% CI 0.84 to 2.83).
Safety outcomes
No significant difference in adverse events.
Conclusion
In adult patients with sepsis, albumin was not superior to balanced crystalloids with respect to death at day 30.
Reference
Alasdair J Gray, Katherine Oatey, Julia Grahamslaw et al. Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial- The ABC-Sepsis Trial. Crit Care Med. 2024 Oct 1;52(10):1520-1532.
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