DETO2X-AMI
Trial question
What is the effect of routine oxygen therapy in patients with suspected acute MI who do not have hypoxemia at baseline?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
31.0% female
69.0% male
N = 6629
6629 patients (2023 female, 4606 male).
Inclusion criteria: patients with suspected acute MI and an oxygen saturation of ≥ 90% on pulse oximetry.
Key exclusion criteria: patients receiving ongoing oxygen therapy, presenting with cardiac arrest or had a cardiac arrest between presentation and enrollment.
Interventions
N=3311 oxygen therapy (supplemental oxygen at 6 L/min for 6-12 hours through an open face mask).
N=3318 no supplemental oxygen.
Primary outcome
All-cause death at 1 year
5%
5.1%
5.1 %
3.8 %
2.5 %
1.3 %
0.0 %
Oxygen
therapy
No supplemental
oxygen
No significant
difference ↔
No significant difference in all-cause death at 1 year (5% vs. 5.1%; HR 0.97, 95% CI 0.79 to 1.21).
Secondary outcomes
No significant difference in the rate of rehospitalization with MI within 1 year (3.8% vs. 3.3%; HR 1.13, 95% CI 0.88 to 1.46).
Conclusion
In patients with suspected acute MI and an oxygen saturation of ≥ 90% on pulse oximetry, oxygen therapy was not superior to no supplemental oxygen with respect to a all-cause death at 1 year.
Reference
Hofmann R, James SK, Jernberg T et al. Oxygen Therapy in Suspected Acute Myocardial Infarction. N Engl J Med. 2017 Sep 28;377(13):1240-1249.
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