Home Sleep and Metabolism
Trial question
What is the effect of sleep extension among adults with overweight who habitually decreased their sleep duration?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
49.0% female
51.0% male
N = 80
80 patients (39 female, 41 male).
Inclusion criteria: overweight adults with habitual sleep duration < 6.5 hours per night.
Key exclusion criteria: obstructive sleep apnea; insomnia or history of any other sleep disorder; night shift; rotating shift work; patients following a weight-loss regimen.
Interventions
N=40 sleep extension (sleep hygiene counseling aiming to extend sleep duration to 8.5 hours for 2 weeks).
N=40 habitual sleep (continued habitual sleep without intervention for 2 weeks).
Primary outcome
Energy intake
-155.5 kcal/d
114.9 kcal/d
77.8 kcal/d
38.9 kcal/d
0.0 kcal/d
-38.9 kcal/d
-77.8 kcal/d
-116.6 kcal/d
-155.5 kcal/d
Sleep
extension
Habitual
sleep
Significant
decrease ▼
Significant decrease in energy intake (-155.5 kcal/d vs. 114.9 kcal/d; AD -270.4 kcal/d, 95% CI -393.4 to -147.4).
Secondary outcomes
No significant difference in total energy expenditure (-46.7 kcal/d vs. 7.2 kcal/d; AD -53.9 kcal/d, 95% CI -134.9 to 27.1).
Significant decrease in weight (-0.48 kg vs. 0.39 kg; AD -0.87 kg, 95% CI -1.39 to -0.35).
Significant decrease in fat-free mass (-0.36 kg vs. 0.26 kg; AD -0.62 kg, 95% CI -1.02 to -0.23).
Conclusion
In overweight adults with habitual sleep duration < 6.5 hours per night, sleep extension was superior to habitual sleep with respect to energy intake.
Reference
Esra Tasali, Kristen Wroblewski, Eva Kahn et al. Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial. JAMA Intern Med. 2022 Apr 1;182(4):365-374.
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