MIND
Trial question
What is the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay Diet in cognitively unimpaired older adults?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
65.0% female
35.0% male
N = 604
604 patients (393 female, 211 male).
Inclusion criteria: adults, aged ≥ 65 years, without cognitive impairment but with a family history of dementia.
Key exclusion criteria: heavy alcohol use; severe illness; cognitive impairment; psychiatric illness.
Interventions
N=301 MIND diet (hybrid of Mediterranean and DASH diet for 3 years).
N=303 control diet (usual diet with mild caloric restriction for weight loss for 3 years).
Primary outcome
Improvement in global cognition scores
0.205 points
0.17 points
0.2 points
0.2 points
0.1 points
0.1 points
0.0 points
MIND
diet
Control
diet
No significant
difference ↔
No significant difference in improvement in global cognition scores (0.205 points vs. 0.17 points; MD 0.035, 95% CI -0.02 to 0.09).
Secondary outcomes
No significant difference in white matter hyperintensities at 3 years (0.086 vs. 0.105; MD -0.019, 95% CI -0.05 to 0.01).
No significant difference in hippocampal volume at 3 years (-0.075 vs. -0.08; MD 0.005, 95% CI -0.02 to 0.03).
No significant difference in gray and white matter at 3 years (-0.016 vs. -0.017; MD 0.001, 95% CI 0 to 0.01).
Conclusion
In adults, aged ≥ 65 years, without cognitive impairment but with a family history of dementia, MIND diet was not superior to control diet with respect to improvement in global cognition scores.
Reference
Lisa L Barnes, Klodian Dhana, Xiaoran Liu et al. Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons. N Engl J Med. 2023 Aug 17;389(7):602-611.
Open reference URL