REDOX
Trial question
What is the role of long-term oxygen supplementation for at least 24 hours per day in patients with severe hypoxemia?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
59.0% female
41.0% male
N = 241
241 patients (141 female, 100 male).
Inclusion criteria: patients who were starting oxygen therapy for chronic severe hypoxemia at rest.
Key exclusion criteria: active smoking; anticipated repeated contact with fire; inability to safely adhere to long-term oxygen therapy or other treatments used in the trial; inability to provide written informed consent.
Interventions
N=117 long-term O2 therapy for 24 hr/day (supplemental oxygen prescribed for 24 hours per day).
N=124 long-term O2 therapy for 15 hr/day (supplemental oxygen while sleeping during the nighttime and not exceeding oxygen use for a total of 9 hours during the daytime).
Primary outcome
Rate of hospitalization or death from any cause within 1 year
64.1%
63.7%
64.1 %
48.1 %
32.0 %
16.0 %
0.0 %
Long-term O2 therapy for 24
hr/day
Long-term O2 therapy for 15
hr/day
No significant
difference ↔
No significant difference in the rate of hospitalization or death from any cause within 1 year (64.1% vs. 63.7%; HR 0.99, 99% CI 0.72 to 1.36).
Secondary outcomes
No significant difference in death from any cause (31.6% vs. 27.4%; HR 1.26, 95% CI 0.79 to 2.01).
No significant difference in hospitalization for any cause (57.3% vs. 57.3%; HR 1, 95% CI 0.72 to 1.4).
No significant difference in mean Functional Assessment of Chronic Illness Therapy scale score for fatigue (22.51 vs. 22.2; MD 0.31, 95% CI -4.07 to 4.7).
Safety outcomes
No significant difference in adverse events.
Conclusion
In patients who were starting oxygen therapy for chronic severe hypoxemia at rest, long-term O2 therapy for 24 hr/day was not superior to long-term O2 therapy for 15 hr/day with respect to the rate of hospitalization or death from any cause within 1 year.
Reference
Magnus Ekström, Anders Andersson, Savvas Papadopoulos et al. Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia. N Engl J Med. 2024 Sep 19;391(11):977-988.
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