ZOE METHOD
Trial question
What is the role of personalized dietary program in adults reflective of the average US population?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
86.0% female
14.0% male
N = 347
347 patients (300 female, 47 male).
Inclusion criteria: individuals, aged 41-70 years, reflective of the average US population.
Key exclusion criteria: receiving medications or supplements (including fish oil) affecting lipids; ongoing inflammatory disease; cancer in the last 3 years; chronic gastrointestinal disorder; receipt of immunosuppressants, corticosteroids, or antibiotics in the last 3 months.
Interventions
N=177 personalized dietary program (dietary advice using the ZOE 2022 algorithm to produce personalized food scores delivered during an 18-week program alongside more generalized nutrition and lifestyle education through a remote mobile phone application).
N=170 general advice (standard care dietary advice).
Primary outcome
Reduction in serum triglyceride concentration at 18 weeks
0.21 mmol/L
0.07 mmol/L
0.2 mmol/L
0.2 mmol/L
0.1 mmol/L
0.1 mmol/L
0.0 mmol/L
Personalized dietary
program
General
advice
Significant
increase ▲
Significantly greater reduction in serum triglyceride concentration at 18 weeks (0.21 mmol/L vs. 0.07 mmol/L; MD 0.13, 95% CI 0.01 to 0.07).
Secondary outcomes
No significant difference in reduction in serum LDL-C concentration at 18 weeks (0.01 mmol/L vs. -0.04 mmol/L; MD 0.04, 95% CI -0.08 to 0.16).
Significantly greater reduction in body weight at 18 weeks (2.17 kg vs. -0.3 kg; MD 2.46, 95% CI 1.25 to 3.67).
Significantly greater reduction in waist circumference at 18 weeks (2.94 cm vs. 0.59 cm; MD 2.35, 95% CI 0.63 to 4.07).
Conclusion
In individuals, aged 41-70 years, reflective of the average US population, personalized dietary program was superior to general advice with respect to reduction in serum triglyceride concentration at 18 weeks.
Reference
Kate M Bermingham, Inbar Linenberg, Lorenzo Polidori et al. Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nat Med. 2024 Jul;30(7):1888-1897.
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